Question 1

When a cell loses telomerase activity, what is the predicted effect?

Accepted Answer

A)  Telomeres will increase slightly with each cell division.
B)  After 30-50 divisions, the cell will show signs of senescence and then die.
C)  An immune stem cell will increase white blood cell production.
D)  A normal somatic cell will gain the ability to divide indefinitely.
E)  The cell will die immediately.

Question 2

Which pieces of evidence support the radial loop-scaffold model of DNA packaging?

Accepted Answer

A)  Histone-depleted metaphase chromosomes still maintain their X-like shapes.
B)  Radial loop-scaffold DNA has been isolated and crystallized.
C)  Topoisomerase II assists in 100 Å packaging.
D)  Each G band formed by Giemsa staining represents a chromatin loop.

Question 3

The position of a gene located within a light G band on the short arm of chromosome 5 could be designated as

Accepted Answer

A)  5p13-pter.
B)  5p13-qter.
C)  p513.
D)  5q13-qter.
E)  q513.

Question 4

The creation of yeast artificial chromosomes preceded the production of the first yeast

Accepted Answer

A)  synthetic chromosome that includes sequences from the human genome.
B)  synthetic chromosome that lacks about 50,000 bp from the normal yeast third chromosome.
C)  essential chromosome that combines the 1000 essential yeast genes into one chromosome.
D)  circular chromosome that does not require telomere sequences.

Question 5

The histone that appears to be responsible for organizing the 100 Å fibers into 300 Å fibers is

Accepted Answer

A)  H4.
B)  H3.
C)  H2.
D)  H1.

Question 6

Histones and DNA have a strong attraction for each other because

Accepted Answer

A)  DNA is positively charged and histones are negatively charged.
B)  both DNA and proteins are hydrophobic.
C)  DNA is negatively charged and histones are positively charged.
D)  like substances share common charges.

Question 7

In DNA, the 300 Å fiber is formed into structural loops.Responsibility for this function appears to lie with

Accepted Answer

A)  histone H4.
B)  nucleosomase.
C)  histone H1.
D)  certain nonhistone proteins.
E)  remodeling complexes.

Question 8

Position-effect variegation of red and white eye color in Drosophila produces

Accepted Answer

A)  one red eye and one white eyes.
B)  two red or two white eyes depending on which gene is dominant.
C)  eyes alternating red and white eye facets.
D)  eyes with red and white patches of varying sizes and positions.

Question 9

In what stage of mitosis are the highly-compacted chromosomes used for FISH?

Accepted Answer

A)  prophase
B)  metaphase
C)  anaphase
D)  telophase
E)  never achieves this level of compaction

Question 10

Acetylated histone tail lysines are associated with chromatin that is

Accepted Answer

A)  open.
B)  closed.
C)  transcriptionally inactive.
D)  newly replicated.
E)  about to replicate.

Question 11

What is the best definition for the FISH technique?

Accepted Answer

A)  A method to fluorescently label different genes on metaphase chromosomes.
B)  A method to fluorescently label methylated histones associated with chromosomes.
C)  A method to fluorescently label heterochromatin.
D)  A method to fluorescently label euchromatin.

Exam 12: The Eukaryotic Chromosome

Position-effect variegation of red and white eye color in Drosophila produces

Correct Answer
verified

Histones and DNA have a strong attraction for each other because

Correct Answer
verified

The histone that appears to be responsible for organizing the 100 Å fibers into 300 Å fibers is

Correct Answer
verified

Which pieces of evidence support the radial loop-scaffold model of DNA packaging?

Correct Answer
verified

What is the best definition for the FISH technique?

Correct Answer
verified

When a cell loses telomerase activity, what is the predicted effect?

Correct Answer
verified

The creation of yeast artificial chromosomes preceded the production of the first yeast

Correct Answer
verified

The position of a gene located within a light G band on the short arm of chromosome 5 could be designated as

Correct Answer
verified

In DNA, the 300 Å fiber is formed into structural loops.Responsibility for this function appears to lie with

Correct Answer
verified

In what stage of mitosis are the highly-compacted chromosomes used for FISH?

Correct Answer
verified

Acetylated histone tail lysines are associated with chromatin that is

Correct Answer
verified

Exam 12: The Eukaryotic Chromosome

Position-effect variegation of red and white eye color in Drosophila produces

Correct AnswerverifiedShow Answer

Histones and DNA have a strong attraction for each other because

Correct AnswerverifiedShow Answer

The histone that appears to be responsible for organizing the 100 Å fibers into 300 Å fibers is

Correct AnswerverifiedShow Answer

Which pieces of evidence support the radial loop-scaffold model of DNA packaging?

Correct AnswerverifiedShow Answer

What is the best definition for the FISH technique?

Correct AnswerverifiedShow Answer

When a cell loses telomerase activity, what is the predicted effect?

Correct AnswerverifiedShow Answer

The creation of yeast artificial chromosomes preceded the production of the first yeast

Correct AnswerverifiedShow Answer

The position of a gene located within a light G band on the short arm of chromosome 5 could be designated as

Correct AnswerverifiedShow Answer

In DNA, the 300 Å fiber is formed into structural loops.Responsibility for this function appears to lie with

Correct AnswerverifiedShow Answer

In what stage of mitosis are the highly-compacted chromosomes used for FISH?

Correct AnswerverifiedShow Answer

Acetylated histone tail lysines are associated with chromatin that is

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified