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In the humoral response, some B cells differentiate into plasma cells.What do plasma cells produce in large quantities?


A) agglutinations that are specific for foreign antibodies
B) interferons specific for foreign antigens
C) immunoglobulins specific for foreign antigens
D) antigens specific for foreign antibodies

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A patient has come to you for a second opinion."I have these mysterious lumps in my right armpit," he says, "The other doctor says we may have to remove them.What do you think?" You notice red scratches on the patient's right arm."You must have a new kitten.Cat scratch disease, from the bacterium Bartonella ," you say, "And we certainly won't remove those lumps, they are really important! Those are your..."


A) "thymus glands, where naive B and T cells encounter antigens and become activated."
B) "lymph nodes, where T-cell receptor genes are rearranged as T cells mature."
C) "lymph nodes, where naive B and T cells encounter antigens and become activated."
D) "spleen, where hematopoietic stem cells produce lymphoid and myeloid progenitors."

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Which mechanism allows certain viral pathogens to evade the vertebrate immune system?


A) becoming a symbiont
B) becoming nonvirulent
C) frequent changing of surface antigens
D) becoming metabolically inactive

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The surface defenses of the body consist of the ______ and the mucous membranes lining the digestive and respiratory tracts.


A) bone marrow
B) skin
C) T cells
D) lymphocytes

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The cell-mediated immune response is brought about by which cells?


A) B cells
B) T cells
C) erythrocytes
D) fibroblasts

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Unless rare antigens are present ideally, a patient needing a transfusion will receive blood of the identical blood type.But in an emergency, what blood type can be given in a transfusion to anyone?


A) AB Rh-positive
B) AB Rh-negative
C) O Rh-negative
D) O Rh-positive

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What is the blood type of individuals who lack antigens on their red blood cell surfaces?


A) A, Rh+
B) B, Rh+
C) AB, Rh-
D) O, Rh-.

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Which of the following describes passive immunity?


A) antibodies transferred to the fetus from the mother across the placenta
B) vaccination for polio
C) allowing oneself to become infected with chicken pox
D) vaccination for influenza

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What molecules are released by activated helper T cells?


A) antigens
B) immunoglobulins
C) cytokines
D) antibodies

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What are the source of antibody-producing cells?


A) B cells
B) macrophages
C) plasma cells
D) T cells

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Two proteins, Rag-1 and Rag-2, catalyze VDJ recombination.Where would you expect these proteins to be expressed?


A) thyroid and parathyroid
B) bone marrow only
C) bone marrow and thymus
D) thyroid only

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When a "new" antigen first challenges the immune system, if the primary immune response produces B cells, what are the fates of those B cells? I-Some of the B cells become plasma cells that secrete antibodies.II-Some of the B cells become memory cells and can produce a swifter response if the body encounters that particular antigen again.III-Some of the B cells secrete chemicals called pyrogens that travel to the brain inducing a fever.


A) just II
B) just I
C) II and III
D) I and II

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In the old days, milkmaids were exposed to cowpox from milking the cows, and this fortuitously gave them some protection from smallpox.What was happening in the milkmaids?


A) They were receiving a dose of generic IgG from the sick cows.
B) They were effectively receiving a vaccination from a related virus.
C) They were heightening their overall immune response due to exposure to the cowpox and other cow parasites.
D) They had a stronger immune response from drinking the milk, which sent cow B cells circulating through their blood.

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Two proteins, Rag-1 and Rag-2, catalyze VDJ recombination.What is the likely outcome of a deletion of the Rag genes?


A) mild susceptibility to infection due to T cell defects
B) increased antibody diversity from B cells
C) severe combined immunodeficiency (SCID) of both B and T cells
D) increased resistance to infection due to enhanced B and T cell function

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You sit next to Uncle Ed, an immunologist, at Thanksgiving dinner."I'm a 'big eater'", he says, "just like the cells I study." What are the large cells that engulf pathogens that Uncle Ed works with?


A) monocytes
B) erythrocytes
C) macrophages
D) bacteriophages

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Which cells produce specific antibodies?


A) B cells
B) macrophages
C) plasma cells
D) T cells

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Select the correct statement regarding the temperature response of the immune system.


A) When macrophages encounter invading cells, they release immunoglobulin-1, which is carried to the brain by the circulatory system.
B) Interleukin-1 is a pyrogen, which can cause the neurons in the hypothalamus to raise the body's temperature, producing a fever.
C) Fever contributes to the body's defenses by stimulating hyperhidrosis and causing the liver and spleen to store magnesium.
D) Fevers above 99 °\degree F are often fatal.

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What is another term for allergy?


A) autoimmunity
B) antibodies
C) hypersensitivity
D) antigen shifting

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What would happen to immunoglobulin genes if alternative mRNA splicing was nonfunctional?


A) Transcripts would contain a single V region only.
B) Transcripts would contain all possible V, D, J, and constant regions.
C) Transcripts would have extra V, D, and J segments attached to a single constant region.
D) Transcripts would have single V and D segments, but extra J segments and constant regions.

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Where are MHC_II cell surface proteins found?


A) macrophages, B cells, and dendritic cells
B) erythrocytes
C) acidophils
D) neutrophils

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