Question 1

Receptors for steroid hormones are usually found in the nucleus of the cell.

Accepted Answer

A) True 
 B)False

Question 2

Steroid hormomes are an example of an effector which regulates regulatory transcription factor
activity.

Accepted Answer

A) True 
 B)False

Question 3

Explain why yeast genes with a single intron have essentially no alternative splicing.

Accepted Answer

A)   Yeast genes never have alternative splicing.
B)   Removal of a single intron leads to splicing of the poly-A tail which prevents further splicing.
C)   Methylation of the single intron prevents further splicing.
D)   Removal of a single intron only leads to one possible outcome for spliced mRNA.
E)   None of the above.

Question 4

In which of the following scenarios would gene expression be the lowest?

Accepted Answer

A)   The CpG island upstream of the gene is unmethylated
B)   Injecting antisense RNA corresponding to the mRNA of the gene
C)   Deletion of a sequence upstream of the gene known to be a silencer
D)   Injecting double-stranded RNA corresponding to the mRNA of the gene

Question 5

Which mechanisms are used by miRNAs to regulate gene expression?

Accepted Answer

A)   Targeted degradation of mRNAs
B)   Targeted inhibition of mRNA translation
C)   Both A and B
D)   Neither A nor B

Question 6

Which of the following is incorrect regarding the glucocorticoid hormomes?

Accepted Answer

A)   They interact with receptors located in the plasma membrane of the cell
B)   After interacting with the receptor, they release HSP90
C)   The receptors form a homodimer that travels to the nucleus
D)   The homodimer interacts with GRE, activating transcription A

Question 7

Which of the following is a steroid receptor?

Accepted Answer

A)   GRE
B)   IRE
C)   CRE
D)   None of the answers are correct

Question 8

DNA that contains actively transcribed genes would most likely contain chromatin in the closed
configuration.

Accepted Answer

A) True 
 B)False

Question 9

The exons of a gene are always expressed in a functional protein.

Accepted Answer

A) True 
 B)False

Question 10

A mutation in which of the following would result in little or no expression of a gene regulated by a CRE?

Accepted Answer

A)   G protein
B)   Adenylyl cyclase
C)   Protein kinase A
D)   All of the answers are correct

Question 11

What structural motifs promote dimerization?

Accepted Answer

A)   Zinc finger
B)   Leucine zipper
C)   Helix-turn-helix
D)   Helix-loop-helix

Question 12

A repressor protein would enhance the ability of TFIID to bind to the TATA box of the promoter.

Accepted Answer

A) True 
 B)False

Question 13

Genomic imprinting is a result of .

Accepted Answer

A)   Nucleosome location
B)   Histone activation
C)   DNA methylation
D)   Serine to leucine changes in the genetic code

Question 14

Histone acetyltransferases would be directly involved in which of the following?

Accepted Answer

A)   Formation of open chromatin
B)   Movement of the nucleosome
C)   Acetylation of lysines
D)   Termination of gene expression

Question 15

cAMP is known as a second messenger system since the pathway is first activated by a extracellular
signaling molecule

Accepted Answer

A) True 
 B)False

Question 16

eIF2a is phosphorylated in order to inhibit transcription. What is occurring at the molecular level?

Accepted Answer

A)   Phosphorylated eIF2a binds to tRNAs, preventing them from attaching its amino acid
B)   Phosphorylated eIF2a binds to eIF2B, inhibiting its activity
C)   Phosphorylated eIF2a binds to the mRNA, blocking the Shine-Delgarno sequence and preventing translational initiation
D)   All of the answers are correct

Question 17

Based on the following mature mRNAs, what exons are constitutive? I. 1-2-3-4-7-8-10 II. 2-4-5-6-7-9 III. 1-4-6-7-8 IV. 1-2-4-7-10

Accepted Answer

A)   1 and 2
B)   1 and 4
C)   2 and 7
D)   4 and 7

Question 18

A heterodimer occurs when two identical transcription factors interact on a sequence of DNA.
FALSE

Accepted Answer

A) True 
 B)False  False

Question 19

What basal transcription factor is most often affected by regulatory transcription factors?

Accepted Answer

A)   TFIIB
B)   TFIID
C)   TFIIE
D)   TFIIF

Question 20

Activator proteins bind to silencer sequences and repressor proteins bind to enhancer sequences.

Accepted Answer

A) True 
 B)False  False

Exam 15: Gene Regulation in Eukaryotes

Receptors for steroid hormones are usually found in the nucleus of the cell.

Correct AnswerverifiedShow Answer

Steroid hormomes are an example of an effector which regulates regulatory transcription factor activity.

Correct AnswerverifiedShow Answer

Explain why yeast genes with a single intron have essentially no alternative splicing.

Correct AnswerverifiedShow Answer

In which of the following scenarios would gene expression be the lowest?

Correct AnswerverifiedShow Answer

Which mechanisms are used by miRNAs to regulate gene expression?

Correct AnswerverifiedShow Answer

Which of the following is incorrect regarding the glucocorticoid hormomes?

Correct AnswerverifiedA

Which of the following is a steroid receptor?

Correct AnswerverifiedShow Answer

DNA that contains actively transcribed genes would most likely contain chromatin in the closed configuration.

Correct AnswerverifiedShow Answer

The exons of a gene are always expressed in a functional protein.

Correct AnswerverifiedShow Answer

A mutation in which of the following would result in little or no expression of a gene regulated by a CRE?

Correct AnswerverifiedShow Answer

What structural motifs promote dimerization?

Correct AnswerverifiedShow Answer

A repressor protein would enhance the ability of TFIID to bind to the TATA box of the promoter.

Correct AnswerverifiedShow Answer

Genomic imprinting is a result of .

Correct AnswerverifiedShow Answer

Histone acetyltransferases would be directly involved in which of the following?

Correct AnswerverifiedShow Answer

cAMP is known as a second messenger system since the pathway is first activated by a extracellular signaling molecule

Correct AnswerverifiedShow Answer

eIF2a is phosphorylated in order to inhibit transcription. What is occurring at the molecular level?

Correct AnswerverifiedShow Answer

Based on the following mature mRNAs, what exons are constitutive? I. 1-2-3-4-7-8-10 II. 2-4-5-6-7-9 III. 1-4-6-7-8 IV. 1-2-4-7-10

Correct AnswerverifiedShow Answer

A heterodimer occurs when two identical transcription factors interact on a sequence of DNA. FALSE

Correct AnswerverifiedFalse

What basal transcription factor is most often affected by regulatory transcription factors?

Correct AnswerverifiedShow Answer

Activator proteins bind to silencer sequences and repressor proteins bind to enhancer sequences.

Correct AnswerverifiedFalse

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A

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False

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False