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The majority of mature, self-tolerant lymphocytes are found in


A) the MALT.
B) lymph nodes.
C) the thymus.
D) the spleen.
E) the tonsils.

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A single B lymphocyte can recognize multiple antigenic determinants.

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Enhanced immune responses to subsequent exposures to an antigen to which the body has already been exposed are known as ________ responses.


A) third-degree immune
B) allergic
C) primary immune
D) memory
E) autoimmune

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Class II MHC are found on


A) the skin.
B) red blood cells.
C) cytoplasmic membranes of nucleated cells.
D) muscle cells.
E) professional antigen-presenting cells.

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Plasma cells produce (antibody/chemokine/cytotoxic) molecules.

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Which of the following is a characteristic of the third line of defense that makes it significantly different from the second line?


A) The response is specific to a single antigen.
B) The initial response is very rapid, beginning in minutes to a couple of hours.
C) The response is effective on a broad range of antigens.
D) The response to a second exposure is similar to the response to a first exposure.
E) The responding cells are a variety of cell types.

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A sick child may have influenza or RSV. These virus infections have different treatment options, so the physician requests antibody titer tests. The results are as follows: anti-influenza antibodies are primarily IgM, and anti-RSV antibodies are all IgA and IgG. Which of the following is the most appropriate interpretation?


A) the child has a current RSV infection and was previously exposed to influenza.
B) the child currently has influenza and has previously been exposed to RSV.
C) the child has concurrent influenza and RSV infections.
D) the child has neither influenza nor RSV.
E) the results do not provide sufficient data to draw a conclusion.

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Which of the following statements regarding the cell-mediated immune response is TRUE?


A) Cytotoxic T lymphocytes do not require antigen presentation to become activated.
B) Cytotoxic T lymphocytes interact with antibodies that have bound antigen to identify their target.
C) Helper T lymphocytes have no role in the activation of cytotoxic T lymphocytes.
D) Cytotoxic T lymphocytes kill by producing hydrogen peroxide.
E) A single cytotoxic T lymphocyte can kill many target cells.

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CTLs use the CD95 molecule to recognize their epitope.

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Activation of B lymphocytes produces (antibody-mediation/cell-mediated/innate) immune responses.

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Which of the following is an exogenous antigen?


A) a bacterium inside a cell
B) a virus inside a cell
C) a bacterium outside a cell
D) a noninfected human cell
E) the malaria parasite inside a red blood cell

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The white blood cells primarily responsible for adaptive immunity are


A) NK lymphocytes and neutrophils.
B) B lymphocytes and T lymphocytes.
C) macrophages and eosinophils.
D) macrophages and neutrophils.
E) neutrophils and dendritic cells.

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Describe the mechanisms of action of antibodies.

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Antibodies act against foreign antigens ...

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Which of the following statements concerning plasma cells is FALSE?


A) They live for many years and function as memory cells.
B) They are descended from activated B cells.
C) They can produce large quantities of antibodies on a daily basis.
D) They secrete a single type of antibody molecule specific for a single epitope.
E) The antibodies they produce can remain in circulation for weeks.

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Discuss the importance of there being two types of adaptive immune responses (antibody and cell-mediated).

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Pathogens (and other hazards to the body...

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B cells are activated when they interact with (antigen-presenting/Th1/Th2) cells.

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The delay in the initial adaptive immune response to pathogen is largely due to the (inducibility/memory/specificity) of adaptive immunity.

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Adaptive immunity is sometimes also called acquired immunity. Which of the following statements provides a basis for the alternative name?


A) Lymphocytes of the adaptive immune system are highly specific for a single epitope.
B) Activated lymphocytes produce daughter cells that are identical in specificity and function.
C) To become activated, lymphocytes require exposure to the epitope for which they are specific.
D) Activated lymphocytes may persist for years in the body.
E) Lymphocytes reactive to normal body components are removed.

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Which of the following statements concerning B cell receptors (BCRs) is FALSE?


A) They are formed in response to an encounter with an antigen.
B) They are complementary in shape to a specific antigenic determinant that they may or may not encounter.
C) They are bound to the surface of B lymphocytes and have two antigen-binding sites.
D) Each B lymphocyte is randomly generated with antibody variable regions that determine its BCR.
E) Scientists estimate that each person forms at least 10ยนยน different types of B lymphocytes with distinct BCRs.

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The most prevalent antibody class in the blood is


A) IgD.
B) IgM.
C) IgA.
D) IgG.
E) IgE.

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