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When two genes on the same chromosome are located 10 map units from each other, ____ of the offspring from a testcross for genetic linkage should have a recombinant phenotype.


A) over 75%
B) about 50%
C) about 25%
D) about 10%
E) about 5%

F) All of the above
G) C) and E)

Correct Answer

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Which individual may be a carrier for a recessive X-linked trait in humans?


A) a homozygous recessive male
B) a homozygous recessive female
C) a homozygous dominant female
D) a heterozygous female
E) a heterozygous male

F) B) and E)
G) All of the above

Correct Answer

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One mechanism of genomic imprinting silences an allele by DNA ____.


A) methylation
B) mutation
C) transposition
D) deletion
E) inversion

F) All of the above
G) A) and B)

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Choose the mode of inheritance that has been determined for each of the following genetic conditions in humans. Some choices may be used more than once.

Premises
achondroplasia
sickle-cell anemia
red-green colorblindness
Down syndrome
Duchenne muscular dystrophy
hereditary enamel hydroplasia
progeria
phenylketonuria
cystic fibrosis
Responses
X-linked dominant
autosomal dominant
autosomal recessive
X-linked recessive
aneuploidy

Correct Answer

achondroplasia
sickle-cell anemia
red-green colorblindness
Down syndrome
Duchenne muscular dystrophy
hereditary enamel hydroplasia
progeria
phenylketonuria
cystic fibrosis

In Drosophila melanogaster, the gene for eye color is located on the X chromosome. The allele for red eye color (Xw+) is dominant over the allele for white eye color (Xw) . You examine a vial of 100 flies that are all offspring from a single genetic cross. You find both red-eyed females and white-eyed females as well as both red-eyed males and white-eyed males. The genotypes of the parents were ____.


A) Xw+Xw+; XwY
B) Xw+Xw; XwY
C) XwXw; Xw+Y
D) Xw+Xw; Xw+Y
E) XwXw; XwY

F) A) and C)
G) C) and D)

Correct Answer

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You are observing a number of human uterine cells with a microscope. In the nucleus of each cell, you can see a mass of condensed heterochromatin at one side of the nucleus. Which chromosome is likely to be included in the condensed heterochromatin?


A) a Y chromosome
B) chromosome 21
C) an X chromosome
D) chromosome 5
E) the Philadelphia chromosome

F) A) and D)
G) A) and C)

Correct Answer

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You are working in a research lab on the organism Drosophila melanogaster , and you have been given the job of determining the relative positions of three linked genes for your undergraduate research project. A graduate student in the lab tells you that gene a is 5.0 centimorgans from gene b , and that gene c is 2.7 centimorgans from gene b . What should you do to finish mapping these three genes? What are the likely results that may occur, and how would you interpret such results?

Correct Answer

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To complete this task, you should perfor...

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Which genetic condition has an X-linked recessive inheritance pattern?


A) Duchenne muscular dystrophy
B) phenylketonuria
C) achondroplasia
D) sickle-cell anemia
E) cystic fibrosis

F) A) and E)
G) C) and D)

Correct Answer

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If two genes are linked on the same chromosome, then ____.


A) they tend to segregate away from one another during meiosis
B) the more crossing-over occurs between them
C) the less crossing-over occurs between them
D) they tend to segregate away from one another during mitosis
E) they control the same trait

F) A) and E)
G) A) and B)

Correct Answer

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An autosome is a ____.


A) chromosome other than a sex chromosome
B) structure used to transport genetic material to the cytoplasm
C) chromosome containing a group of genes involved in autoimmune disorders
D) region of the DNA that is self-replicating
E) cellular body involved in autoimmune disorders

F) A) and B)
G) B) and E)

Correct Answer

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The principles of linkage and recombination were discovered using which organism?


A) yeast
B) E. coli
C) viruses
D) fruit flies
E) cattle

F) A) and B)
G) A) and D)

Correct Answer

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A woman with normal blood clotting mates with a man who has hemophilia. Their first child is a boy who has hemophilia. Tests show that the father and son both have the same form of hemophilia, that it is X-linked, and that the boy has normal genetic inheritance. You can predict that if the couple has more children together, it is likely that ____.


A) all of the children will have hemophilia
B) half of the boys and none of the girls will have hemophilia
C) none of the other children should have hemophilia
D) all of the boys and half of the girls will have hemophilia
E) half of the boys and half of the girls will have hemophilia

F) C) and D)
G) B) and E)

Correct Answer

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