Question 1

What effect will a mutation in IRP that prevents it from binding to iron have on an individual?

Accepted Answer

A)   Ferritin will not be made, so iron intake must be maximized.
B)   There will be excess ferritin, so iron intake must be lowered.
C)   Transferrin will not be made, so iron intake must be maximized.
D)   There will be excess transferrin, so iron intake must be lowered.

Question 2

DNA methylation activates gene expression.

Accepted Answer

A) True 
 B)False

Question 3

A repressor protein would enhance the ability of TFIID to bind to the TATA box of the promoter.

Accepted Answer

A) True 
 B)False

Question 4

If a human cell has two Barr bodies then the genotype of the individual could be

Accepted Answer

A)   XXXY
B)   XXXXY
C)   XXY
D)   XYY

Question 5

What are some types of the molecular changes that underlie epigenetic gene regulation?

Accepted Answer

A)   depurination of cytosine and thymidine residues
B)   DNA methylation and chromatin remodeling
C)   DNA methylation and depurination of cytosine residues
D)   depurination and chromatin remodeling

Question 6

Which of the following statements are correct?

Accepted Answer

A)   Changes in gene expression based on environmental conditions are not considered normal while developmental changes are
B)   Environmental epigenetic changes can vary due to the exposure of the organism to different environmental conditions, while those programmed during development are the result of stimuli generated by the organism itself
C)   Environmental epigenetic gene regulation only occurs in reptiles and insects, while developmental epigenetic regulation occurs in all animals
D)   Environmental epigenetic gene regulation is typically reversible while developmental epigenetic gene regulation is typically not reversible.

Question 7

Which of the following is part of the process of X-chromosome inactivation?

Accepted Answer

A)   Expression of Xist from both chromosomes at the start of the process
B)   Binding of multiple Xist transcripts to Xic on the X chromosome that will be inactivated
C)   Compaction of the active X chromosome into a Barr body
D)   Binding of Tsix transcripts to the X chromosome to be inactivated after the Xist transcripts binds to Xic

Question 8

What would be the result of a mutation in HSP90 that blocked HSP90's ability to bind to the glucocorticoid receptor?

Accepted Answer

A)   Glucocorticoid receptor could not form a dimer.
B)   The nuclear localization signal would no longer function.
C)   Glucocorticoid regulated genes would not be controlled even in the absence of  glucocorticoid.
D)   The hormone would not be able to bind to the glucocorticoid receptor.

Question 9

Chromatin remodeling complexes alter nucleosomes,this occurs when

Accepted Answer

A)   remodeling proteins bind to TFIID to promote or inhibit nucleosome formation.
B)   complexes of ATP-dependent protein degrade histones and release the DNA from nucleosomes.
C)   complexes of ATP-dependent proteins may reposition, evict, or change nucleosome composition.
D)   remodeling proteins increase the supercoiling of the DNA, which can inhibit nucleosome formation.

Question 10

A common way of studying methylation in cells is to sequence DNA samples before and after modification with sodium bisulfite. The sodium bisulfite deaminates Cytosine residues,generating Uracil residues,therefore resulting in a change in the sequence as compared to the nonmodified DNA. Sodium bisulfite does not react with 5-methylcytosine so there will be no change in the sequence of those modified bases. When tumors are sequenced to study methylation patterns and epigenetic control,what would be the best control for sequencing using this technique?

Accepted Answer

A)   Noncancerous tissue DNA from a different individual but from the same organ
B)   Liver DNA from the same individual that the cancer sample is from
C)   DNA from noncancerous tissue from the same individual's organ as the cancer
D)   A combination of DNA from liver, brain and muscle from the same individual that has the cancer

Question 11

Covalent histone modification is sometimes involved in cell differentiation.

Accepted Answer

A) True 
 B)False

Question 12

CpG islands are associated with which of the following?

Accepted Answer

A)   nucleosome location
B)   DNA methylation
C)   steroid hormone activity
D)   termination of translation

Question 13

Activator proteins bind to silencer sequences and repressor proteins bind to enhancer sequences.

Accepted Answer

A) True 
 B)False

Question 14

Most genes imprinted by methylation are silenced.What is one exception to this rule?

Accepted Answer

A)   H19
B)   Igf2
C)   Xist
D)   Agouti

Question 15

Regulatory transcription factors may influence gene expression in which of the following ways?

Accepted Answer

A)   recruiting proteins to the promoter that enhance chromatin compaction
B)   by directly interacting with TFIII to inhibit its binding to the core promoter
C)   influencing the ability of the RNA polymerase to perform elongation
D)   directly recruiting RNA polymerase to the promoter without interacting with any other proteins

Exam 17: Gene Regulation in Eukaryotes

Chromatin remodeling complexes alter nucleosomes,this occurs when

Correct Answer
verified

Regulatory transcription factors may influence gene expression in which of the following ways?

Correct Answer
verified

What would be the result of a mutation in HSP90 that blocked HSP90's ability to bind to the glucocorticoid receptor?

Correct Answer
verified

Which of the following is part of the process of X-chromosome inactivation?

Correct Answer
verified

Which of the following statements are correct?

Correct Answer
verified

Correct Answer
verified

If a human cell has two Barr bodies then the genotype of the individual could be

Correct Answer
verified

What effect will a mutation in IRP that prevents it from binding to iron have on an individual?

Correct Answer
verified

DNA methylation activates gene expression.

Correct Answer
verified

Covalent histone modification is sometimes involved in cell differentiation.

Correct Answer
verified

Most genes imprinted by methylation are silenced.What is one exception to this rule?

Correct Answer
verified

CpG islands are associated with which of the following?

Correct Answer
verified

Activator proteins bind to silencer sequences and repressor proteins bind to enhancer sequences.

Correct Answer
verified

What are some types of the molecular changes that underlie epigenetic gene regulation?

Correct Answer
verified

A repressor protein would enhance the ability of TFIID to bind to the TATA box of the promoter.

Correct Answer
verified

Exam 17: Gene Regulation in Eukaryotes

Chromatin remodeling complexes alter nucleosomes,this occurs when

Correct AnswerverifiedShow Answer

Regulatory transcription factors may influence gene expression in which of the following ways?

Correct AnswerverifiedShow Answer

What would be the result of a mutation in HSP90 that blocked HSP90's ability to bind to the glucocorticoid receptor?

Correct AnswerverifiedShow Answer

Which of the following is part of the process of X-chromosome inactivation?

Correct AnswerverifiedShow Answer

Which of the following statements are correct?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

If a human cell has two Barr bodies then the genotype of the individual could be

Correct AnswerverifiedShow Answer

What effect will a mutation in IRP that prevents it from binding to iron have on an individual?

Correct AnswerverifiedShow Answer

DNA methylation activates gene expression.

Correct AnswerverifiedShow Answer

Covalent histone modification is sometimes involved in cell differentiation.

Correct AnswerverifiedShow Answer

Most genes imprinted by methylation are silenced.What is one exception to this rule?

Correct AnswerverifiedShow Answer

CpG islands are associated with which of the following?

Correct AnswerverifiedShow Answer

Activator proteins bind to silencer sequences and repressor proteins bind to enhancer sequences.

Correct AnswerverifiedShow Answer

What are some types of the molecular changes that underlie epigenetic gene regulation?

Correct AnswerverifiedShow Answer

A repressor protein would enhance the ability of TFIID to bind to the TATA box of the promoter.

Correct AnswerverifiedShow Answer

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