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Live, attenuated vaccines


A) include the Sabin polio vaccine.
B) include the measles, mumps, rubella vaccine (MMR) .
C) contain viable microbes that can multiply in the person.
D) require smaller doses and fewer boosters compared to inactivated vaccines.
E) All of the choices are correct.

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E

The antibody-secreting progeny cells of a B-cell clone are called


A) plasma cells.
B) antibodies.
C) bursa cells.
D) activated macrophages.
E) sensitized T cells.

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After secreting antibodies during an immune response, plasma cells then differentiate into memory cells.

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During which response to the antigen do we display a latent period of no secretory antibody synthesis?


A) Primary
B) Secondary
C) Tertiary
D) Quaternary

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The monomer subunit of immunoglobulin molecules has all of the following except


A) two identical light polypeptide chains.
B) two identical heavy polypeptide chains.
C) four antigen binding sites.
D) disulfide bonds between polypeptide chains.
E) a variable and constant region on each polypeptide chain.

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A foreign molecule that causes a specific immune response is a(n) ______.


A) PAMP
B) marker
C) antigen
D) hapten
E) antibody

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C

Class I MHC genes code for


A) self receptors recognized by T lymphocytes.
B) all HLA antigens.
C) receptors located primarily on macrophages and B cells.
D) certain secreted complement components.

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Which process involves antibodies covering surface receptors on a virus or toxin molecule, thereby disrupting their activity?


A) Opsonization
B) Neutralization
C) Complement fixation
D) Agglutination
E) Anamnestic response

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Specific immunity provides long-lasting protection through the production of _____.


A) memory cells
B) plasma cells
C) T helper cells
D) antibodies
E) phagocytotic cells

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An example of natural active immunity would be


A) chickenpox infection, followed by lifelong immunity.
B) giving a person immune serum globulins to chickenpox virus after exposure to the disease.
C) a fetus acquiring maternal IgG to the chickenpox virus across the placenta.
D) chickenpox vaccine triggering extended immunity to chickenpox.

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The immunoglobulin class that has an Fc region that binds to receptors on basophils and mast cells is ______.


A) IgA
B) IgG
C) IgM
D) IgD
E) IgE

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All of the following are characteristics of IgM except


A) it can serve as a B-cell receptor.
B) it is a dimer.
C) it is the first class synthesized by a plasma cell.
D) it has 10 antigen binding sites.
E) it contains a central J chain.

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A patient enters your clinic with a suspected helminthic infection.In support of this diagnosis, you suspect elevated levels of which antibody in the patient's serum?


A) IgG
B) IgM
C) IgE
D) IgD

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The molecular fragment on an antigen molecule that a lymphocyte recognizes and responds to is called a(n) ______.


A) hapten
B) antigen binding site
C) variable region
D) epitope

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Which of the following is not a target for TC cells?


A) Pig transplanted heart
B) Human transplanted liver
C) Virus-infected cells
D) Cancer cells
E) Bacteria

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Lymphocyte maturation involves


A) hormonal signals that initiate development.
B) B cells maturing in bone marrow sites.
C) T cells maturing in the thymus.
D) release of mature lymphocytes to begin migration to various lymphoid organs.
E) All of the choices are correct.

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In order for B cells to produce antibodies and cytotoxic T cells to attack infected host cells, they must first


A) recognize self markers, develop specificity for the markers, and then produce clones.
B) be activated by interleukins, encounter an antigen, and then develop specificity toward it.
C) encounter an antigen, develop specificity for that antigen, and then remember the antigen.
D) undergo maturation, encounter their specific antigen target, and then become activated through cytokines.

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B and T lymphocytes are specific; they have only a single type of cell marker on their surface.

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False

Fluzone is a brand name for a very commonly given influenza vaccine.The vaccine is prepared by first harvesting flu viruses in chicken embryos and then breaking apart virus particles into protein subunits, thereby inactivating the virus.Your friend refuses to get the vaccine.Which of these statements is the only valid reason for her not to get the flu vaccine?


A) She could pass the virus onto her baby, causing the child to become autistic.
B) She is allergic to eggs.
C) She could catch the flu from the inactivated vaccine.
D) She could die from the vaccine.

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Vaccinia virus is often used in the technique to make


A) a booster.
B) gamma globulin.
C) an adjuvant.
D) a "Trojan horse" recombinant vaccine.
E) antibodies to toxin.

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