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Which of the following is not true regarding the comparison of type I (slow oxidative) and type II b (fast-glycolytic) skeletal-muscle fibers?


A) Type I fibers have more abundant mitochondria
B) Type I fibers fatigue more readily
C) Type I fibers have more abundant myoglobin
D) Type I fibers have more abundant capillaries
E) Type I motor units contain fewer fibers than type II b motor units

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The site of calcium-ion storage in muscle cells is the lateral sacs of the transverse tubules.

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Unlike skeletal muscle,


A) Smooth muscle is striated
B) Smooth muscle does not have thick and thin filaments
C) Smooth muscle does not use troponin-tropomyosin to regulate cross-bridge activity
D) Smooth muscle does not use changes in cytosolic calcium to regulate cross-bridge activity
E) The myosin in smooth muscle requires phosphorylation before it can bind to ATP

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Which of the following statements about different kinds of skeletal-muscle fibers is true?


A) Slow-oxidative fibers have a greater abundance of glycogen than do fast-glycolytic fibers
B) Fast-glycolytic fibers have a greater abundance of myoglobin than do slow-oxidative fibers
C) Fast-glycolytic fibers can generate greater tension than can slow-oxidative fibers
D) Both slow-oxidative fibers have a greater abundance of glycogen than do fast-glycolytic fibers and fast-glycolytic fibers have a greater abundance of myoglobin than do slow-oxidative fibers are true
E) All of the choices are true

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One cause of fatigue in fast-glycolytic muscle fibers is


A) Depletion of ATP in the fiber
B) Depletion of creatine phosphate in the fiber
C) Depletion of oxygen in the fiber
D) Accumulation of potassium ion in the lumen of T tubules
E) All of the choices are correct

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Smooth-muscle cells may contract in the absence of nervous stimulation.

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Binding of myosin to actin cannot take place in the absence of calcium ion.

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Characteristics of oxidative fibers include numerous mitochondria,abundant myoglobin and large stores of glycogen.

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The optimal length of a skeletal muscle is


A) The length at which the muscle can generate its maximal tetanic tension
B) The shortest length the muscle can achieve while attached to bone, because the amount of overlap between thick and thin filaments is maximal then
C) Approximately the same as its resting length
D) Both the length at which the muscle can generate its maximal tetanic tension and the shortest length the muscle can achieve while attached to bone, because the amount of overlap between thick and thin filaments is maximal then are correct
E) Both the length at which the muscle can generate its maximal tetanic tension and approximately the same as its resting length are correct

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"Motor unit" refers to


A) A single motor neuron plus all the muscle fibers it innervates
B) A single muscle fiber plus all of the motor neurons that innervate it
C) All of the motor neurons supplying a single muscle
D) A pair of antagonistic muscles
E) All of the muscles that affect the movement of any given joint

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Actin is an ATPase.

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The cross-bridge cycle refers to the sequence of events between the time an individual cross bridge binds to a thin filament at the start of a muscle contraction and the time the cross bridge releases the filament at the end of the contraction.

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Which of the following statements regarding skeletal-muscle contraction is true?


A) During a lengthening contraction, the tension exerted by the muscle exceeds the load on the muscle
B) Every isometric contraction begins and ends as an isotonic contraction
C) During every muscle contraction, muscle fibers change length
D) During every muscle contraction, tension is developed in the muscle
E) None of the choices are true

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Organophosphate "nerve gases" induce paralysis by blocking neural stimulation of the neuromuscular junctions,while botulinum toxin produces the same effect by inhibiting acetylcholinesterase.

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During any isometric twitch in a skeletal muscle,


A) Tension exceeds load
B) Tetanus occurs
C) Load exceeds tension
D) The whole muscle shortens

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Excitation-contraction coupling


A) In skeletal-muscle cells requires the influx of extracellular calcium ion
B) In smooth-muscle cells requires the influx of extracellular calcium ion
C) In all kinds of muscle requires the release of calcium ion from the sarcoplasmic reticulum
D) Both in skeletal-muscle cells requires the influx of extracellular calcium ion and in smooth-muscle cells requires the influx of extracellular calcium ion are correct
E) Both in smooth-muscle cells requires the influx of extracellular calcium ion and in all kinds of muscle requires the release of calcium ion from the sarcoplasmic reticulum are correct

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John is a sprinter who specializes in quick and powerful bursts of speed followed by periods of rest.Jim is a marathon runner who specializes in long,steady runs.Compared to John,Jim is likely to have


A) More glycogen stored in his type II b muscle fibers
B) More mitochondria in his type I and II a muscle fibers
C) More myoglobin in his type II b muscle fibers
D) Both more glycogen stored in his type II b muscle fibers and more myoglobin in his type II b muscle fibers
E) Both more mitochondria in his type I and II a muscle fibers and more myoglobin in his type II b muscle fibers

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Fatigued first is typical of which type of skeletal-muscle fibers?


A) Type I
B) Type II

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Multiunit smooth-muscle cells


A) Have individual innervation of each cell
B) Have many gap junctions between cells
C) Respond to stretch by contracting
D) Both have individual innervation of each cell and have many gap junctions between cells are correct
E) Both have individual innervation of each cell and respond to stretch by contracting are correct

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A myofibril is


A) A skeletal-muscle cell
B) Composed of filaments
C) Composed of proteins
D) Both a skeletal-muscle cell and composed of filaments
E) Both composed of filaments and composed of proteins

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